Trump, a NY businessman who has never held elective office, needs a strong performance to improve his chances of getting a boost in opinion polls from the four-day Republican convention as Democrats prepare for their own, more scripted version next week in Philadelphia.
One of her final tweets of the evening was, "This is real-Donald Trump just accepted the @GOP nomination".
Gary Kasparov, former world chess champion and now a dissident Russian politician, said "I've heard this sort of speech a lot in the last 15 years and trust me, it doesn't sound any better in Russian". They also cited Republican infighting over Trump, including the refusal of many high-profile Republicans to endorse the party's new standard-bearer. Cruz called Trump a "pathological liar" and a "narcissist at a level I don't think this country has ever seen".
"I love the media", Trump joked.
Outside the convention hall, Cleveland's Public Square on July 21 attracted hundreds of demonstrators - both supporters and opponents of Trump - amid a sizable police presence. He largely kept to his prepared remarks - and often paused for applause - during his 75-minute speech, the longest presidential acceptance speech in 44 years.
Trump also launched a series of attacks on his Democratic Party rival Hillary Clinton, accusing her of keeping "our rigged system in place" and leaving "death, destruction and weakness" as her legacy. Her record as secretary of state was described as calamitous, and delegates regularly broke into extended chants of "lock her up" in reference to her use of a private email server at the State Department. Trump even said he would make America rich again.More news: In speech of her life, Clinton seeking to dispel doubts
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Echoing promises he has made since hitting the campaign trail 13 months ago, Trump pledged to say he will stop illegal immigration with a wall along the U.S.-Mexico border, and change trade agreements that he claims have sucked manufacturing jobs out of the United States to foreign countries. Justin Buchler, associate professor in the Department of Political Science at Case Western Reserve University, described the speech as "bloody chaos".
"The issues and election outcome are more important than him", he said.
Mr Trump accused Mrs Clinton, his Democratic rival, of utterly lacking the good judgment to serve in the White House and as the military's commander in chief. "And his answer - more fear, more division, more anger, more hate - was yet another reminder that he is temperamentally unfit and totally unqualified to be President of the United States", the Clinton campaign chairman John Podesta said in a statement.
"I hate to admit that maybe he's right... he might not need us", he said.
The drama escalated Wednesday night when U.S. Sen.
Cruz allies have since repeatedly pointed to that low blow from Trump as a reason for refusing to support the Republican nominee. That led to numerous delegates booing him.