"You were here long before any of us were here", Trump said beneath a portrait of former President Andrew Jackson.
"Although, we have a representative in Congress who has been here a long time - longer than you".
Warren has been accused of using her Native American Heritage to get ahead in her political career, particularly in the 2012 MA race for senator, according to the Boston Globe. "They call her [Elizabeth Warren] 'Pocahontas, '" he said.
Despite the controversy surrounding her heritage, Warren told CNN she considered Trump's name-calling a "racial slur" and she "really couldn't believe" the comment. "Pocahontas was a real person - her name was Matoaka", she said.
The seventh president is a source of contention for Native Americans.
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Two Second World War Navajo "code talkers" stood at the podium, with a third seated in a wheelchair as Mr Trump made the remarks, which were greeted with awkward silence.
Critics pointed out Mr Trump's outburst was even more egregious as it was made in front of a portrait of Andrew Jackson, the seventh U.S. president who forced hundreds of thousands of indigenous Americans from their land in the 1830s. "But you know what, I like you because you are special".
And as if all this weren't insult enough, Oglala Lakota journalist and Native Sun News Today publisher Tim Giago cited Trump's tone of voice.
"I think what most people find offensive is Sen". When anchor Alisyn Camerota asked whether it amounted to an ethnic slur, he said yes.
Instead, the comments have drawn the wrath of one Indigenous organisation and Senator Warren has accused the President of making a racial slur.
Warren's claims of Native-American heritage originated during her Senate campaign.