Their trial on 31 healthy men who volunteered for the study found that a 1,200mg-a-day dose of ibuprofen induced compensated hypogonadism within 14 days. A new study says the well-known painkiller could cause fertility issues in males. But a new study raises questions about the risks of frequent usage of ibuprofen by young men.
Researchers published their findings in the Proceedings of the National Academy of Sciences, noting that consumption of ibuprofen resulted in "compensated hypogonadism", a condition in which men have normal levels of testosterone but higher levels of the luteinizing hormone, which stimulates the production of testosterone, The International Study for Sexual Medicine said.
Within just two weeks, it seems that the testosterone-producing hormones in the subjects became linked to the amount of ibuprofen in their blood. As this happened, the ratio of testosterone to luteinizing hormones decreased.
Though the exact reasons for the decline are not yet known; in a recent study, researchers have linked male infertility to Ibuprofen - a common painkiller.
The research focused on men given 600mg of ibuprofen twice a day, which isn't the norm for the average bloke.
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14 of them were given daily doses of Ibuprofen, which professional and amateur athletes take.
Clinically, this condition is called "compensated hypogonadism"-"hypogonadism" because the body probably isn't producing testosterone at the appropriate rate, and "compensated" because other hormones have kicked in and gotten testosterone levels to increase. The condition has been associated with an increased probability of reproductive, cognitive, and physical problems, as well as general mortality.
The detrimental effects of daily ibuprofen were almost immediate.
Bernard Jégou, a senior author on the study at the French National Institute of Health and Medical Research, said he saw no problem in people taking ibuprofen to alleviate pain in the short term - for toothache, for example - but warned against taking the drug for months on end if it was not strictly necessary.
William Colledge, professor of reproductive physiology at the University of Cambridge, who was not involved in the research, said: "It's a fascinating study that suggests that men should be cautious about using high doses of ibuprofen for extended periods".