The Red Devils must now put their entire focus on landing either Alderweireld or Maguire, with time running out for them to land the elusive centre-back.
Jerome Boateng was another option but Bayern Munich have not been keen to sanction a loan move.
The transfer window closed on Thursday evening with Jose Mourinho's prediction, made at a news conference earlier in the day, coming in to fruition: Manchester United failed to add any new signings to add to the trio of Fred, Diogo Dalot and Lee Grant, all of whom arrived in July.
Coming in for a world record transfer fee of around £89 million, the World Cup victor took a while to get going back in Manchester, but he did help the club win both the League Cup and the Europa League in his first season back.
Supporters of both Newcastle and Tottenham would have hoped for more from their clubs during the transfer window, but there will be some new faces on show from the home side, at least.More news: Amnesty International calls for united front against Saudi Arabia
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"I think in the last couple of seasons he's been really, really poor, I think he had a awful World Cup as well".
While optimism is growing at Anfield, the same can not be said at last season's runners-up Manchester United who kick off the new season on Friday at home to Leicester City with a squad that is under-cooked, according to manager Jose Mourinho.
Paul Pogba did not follow suit as the French World Cup winner's frosty relationship with Mourinho has sparked interest from Barcelona.
The Welsh outfit need to get their higher earners out of the door before the window closes, and the Argentine centre-back falls into that category. "The list of injured players is an important list and, after training, I will speak with that group of [World Cup] players because everybody is different, physically and mentally, to see how they feel they are and to understand how they can help or not help". But Mourinho now says he is focusing on the players already at his disposal.
"We have to prepare for this season with good possibilities".
Martin Fisher: Jose Mourinho rarely smiled last season and his expression hasn't changed after a summer of frustration.