England got their UEFA Nation's League campaign off to a losing start on Saturday, with the Three Lions losing 2-1 to Spain in their first competitive defeat at Wembley since a Euro 2008 qualifier against Croatia in November 2007.
De Gea produced an acrobatic save to deny Rashford a second goal shortly afterwards but Spain ended the half on top.
The 23-year-old was having an impressive game, providing an excellent assist for Marcus Rashford to open the scoring at Wembley on Saturday. "Him and John (Stones) being able to rotate positions allowed us to play through midfield better". "We have to keep faith in the way we are trying to play otherwise we go back to what we did historically".
Yet, Saul Niguez hit back in just two minutes before Rodrigo notched what proved the match-winner when he turned in from Thiago Alcantara's free-kick on 31 minutes.More news: NAFTA talks make progress; U.S., Canadian officials to work into night
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"We need to asses over the weekend, but I think it's likely we'll need to call some players in", Southgate said.
"We have got quite a few players short of minutes and a bit of sharpness, so to come into a game like tonight after so long out of the global scene is as tough a test as you can have".
"We'll probably look to do that from the Under-21s, but we just need to see positionally where we stand on Sunday", he added.
England showed exceptional spirit and scored a brilliant goal - playing their way out of their own half before Luke Shaw superbly set-up Marcus Rashford - and while they were dominated by Spain, they did not concede chances. Shaw appeared to be wearing an oxygen mask as he was stabilised on a stretcher and then wheeled off the field. During the World Cup she posed in the Spain goalkeeper's kit and makes a point of congratulating him whenever possible.
"I'm a fighter, I'll be back soon", he wrote on social networks after the game in an attempt to reassure fans.