Throughout the event, several commentators took note of how many people were present at the Democratic senator's campaign launch, cheering her on.
MA senator Elizabeth Warren and South Bend Indiana mayor Pete Buttigieg have announced exploratory committees - used to determine whether a potential candidate should run for office.
Her speech, carried live on USA cable news networks, marked the culmination of a choreographed week-long media plan that has established Ms Harris, 54, as the frontrunner in what is expected to become a very crowded Democratic field. "And we are here because we must answer a fundamental question: who are we?"
Democratic presidential candidate Sen.
During CNN's live broadcast from Drake University in Des Moines, Harris spoke from a stage in front of a friendly audience of Iowans who said they plan to take part in the Democratic caucuses a little more than a year from now. "Of the people. For all the people".
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"Elizabeth Warren kind of got the campaign season started".
When asked during a CNN town hall on Monday about for-profit health care insurers, Harris replied, "Let's eliminate all of that ..." If she ultimately wins the White House she would be the first African-American woman and first person of Asian descent to be president.
"They're serving in our military, they are living productive lives, and this administration has made a decision to vilify them and to trade on them for the sake of this president's medieval vanity project called a wall", she said.
"In 2020, the great likelihood is that an independent would just split the anti-Trump vote and end up re-electing the president", said Bloomberg, who himself considered an independent run three years ago but ultimately backed off. "I don't think we want a 70 percent income tax in America".
Sens. Cory Booker of New Jersey, Sherrod Brown of Ohio, Amy Klobuchar of Minnesota and Bernie Sanders of Vermont may also run.
Trump, clearly aware that a Schultz run could help the sitting president, wasted little time in seeking to goad him into the race, declaring the coffee king "doesn't have the "guts" to run for President!" Law professor Lara Bazleoni in a New York Times op-ed last week cited occasions on which Ms Harris backed contentious policies, and some on social media shared photos of her posing with immigration agents, along with the hashtag #NeverKamala.