While the social media channel only has one post so far, it's likely Harry and Meghan will take to sharing photos of their official engagements and royal outings with their various patronages - and perhaps maybe even some behind-the-scenes glimpses of their royal life in Windsor.
The Royals already operate three official Instagram accounts - @TheRoyalFamily, which focuses on the Queen and other members of the royal family; @ClarenceHouse for Charles and Camilla, the Prince of Wales and Duchess of Cornwall; and @KensingtonRoyal for Prince William and Kate, the Duke and Duchess of Cambridge and up until now, Harry and Meghan.
"I just feel like I'm pretending to be this attractive swan", Smith's Meghan Markle says in the trailer above.
The account follows other royal accounts including Kensington Royal, Clarence House, Prince Andrew, Princess Eugenie and charitable organisations including Heads Together and Well Child.
The Duke and Duchess of Sussex have launched their own Instagram account. "We thank you for your support, and welcome you to @sussexroyal".More news: Brexit: Theresa May offers cross-party talks to break deadlock
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The account has already amassed over 425,000 followers since the announcement by the Kensington Palace Twitter account two hours ago.
Harry and Meghan in Sydney during the Pacific tour.
The royal couple, who tied the knot in May 2018 and are expecting their first child this spring, may have created the Instagram account as a way to share the work and updates of their household, outside of the official Kensington Palace social media accounts, which share all the Royal Family's news.